生物与医学2022researchgate.net
抗血小板和抗凝治疗缓解 24 名 Long COVID 患者症状
Antiplatelet and anticoagulant therapy resolves long covid in 24 patients
入门 · 约 30 分钟读完前置知识：凝血与血小板基础、长新冠基本概念
导读
这篇论文报告对 24 名长新冠（Long COVID / PASC）患者采用抗血小板、抗凝药物联合治疗，针对纤维蛋白淀粉样微血栓和血小板病理，患者持续症状得到缓解。作者强调该方案出血风险高，必须在合格医生严格指导下进行。
HN 关注点：长新冠目前缺乏有效疗法，而'微血栓'假说加上小样本病例显示症状可被'三联'抗凝方案逆转，对 HN 读者既是潜在突破也是争议焦点。
HN 评论精选
这几条评论里：补充 2 亲历 2
补充提醒该疗法出血风险极高，必须在医生监督下进行
这可是个大锤子。请注意论文中这段话：'同时处方质子泵抑制剂泮托拉唑 40mg/天用于胃保护。该方案必须在严格且合格的医疗指导下进行，以避免危险，尤其是出血性出血，以及整体治疗的风险。' 诱导性血友病可不是闹着玩的。
wantsanagent查看英文原文
This is a big hammer. Please note this section: "A proton pump inhibitor (PPI) pantoprazole 40 mg/day was also prescribed for gastric protection. Such a regime must only be followed under strict and qualified medical guidance to obviate any dangers, especially haemorrhagic bleeding, and of the therapy as a whole." Induced hemophilia is no joke.
亲历以父亲康复后手臂症状自行消失的亲历，佐证微血栓假说
微血栓与长新冠之间的联系对我来说很新鲜，也很吸引人。从轶事上看，这和我亲友身上看到的症状吻合。我父亲新冠康复后，多年前骨折的手臂活动能力下降了好几个月。后来某天他稍微用力后，疼痛和受限感完全消失，而原来疼痛部位的皮肤变得有点发黑。我不是医生，但感觉像是微血栓相关？他形容那种疼痛像神经或血管被拧住一样。这个 HN 帖子讨论了更多相关联系：https://news.ycombinator.com/item?id=29808020
cdrini查看英文原文
The link between microclots and long COVID is new to me and fascinating. Anecdotally, this gels with some of the symptoms I've seen in friends/family. My father had reduced motility in his arm-- where he'd broken it many years before--for many months after recovering from COVID. Then one random day, after he'd strained himself a bit, he noticed the pain/restriction completely gone, and the skin had turned slightly black in the region where it used to hurt. Not a doctor, but feels like something related to a microclot? He described the pain as almost like a twisted nerve or vein. This HN post talks more about the link: https://news.ycombinator.com/item?id=29808020
补充认为长新冠可能就是慢性疲劳综合征（ME/CFS），希望研究惠及 CFS 患者
这听起来完全就是慢性疲劳综合征（CFS），我不明白为什么明明有名字还要叫它长新冠。NHS 列出的 ME/CFS 可能诱因包括病毒感染（如腺热）、细菌感染（如肺炎）、免疫系统问题、激素失衡和基因（某些家族更常见）。我有个朋友在疫情前无缘无故得了 CFS，很痛苦，无法治愈，破坏性极大。同时，别人很难认真对待你，只会说你懒。希望这项研究能走下去，让我们找到 CFS 的治愈方法。
jokethrowaway查看英文原文
Sounds exactly like chronic fatigue syndrome, I don't know why we keep calling it Long COVID while we have a name for it. https://www.nhs.uk/conditions/chronic-fatigue-syndrome-cfs/ > Suggested causes or triggers for ME/CFS include: > viral infections, such as glandular fever > bacterial infections, such as pneumonia > problems with the immune system > a hormone imbalance > your genes – ME/CFS seems to be more common in some families I have a friend who got CFS out of nowhere (shortly before the 2 years to flatten the curve started, no COVID involved) and it's bad, there is no cure and it's incredibly disruptive. At the same time, it's hard for people to take you seriously and not just call you lazy. Hopefully this study goes somewhere and we'll find a cure for CFS.
亲历亲历者称阿司匹林似乎缓解了自己的长新冠症状
我打算开始吃阿司匹林了。说来奇怪，之前因为家里没有布洛芬，我吃过几次阿司匹林，确实感觉对我正在经历的奇怪的长新冠症状帮助很大。先说明我是打了三针疫苗的。快速检测我从未测出新冠阳性，但看起来很多人和我处境类似。
JohnJamesRambo查看英文原文
I think I’m going to start taking aspirin. Oddly enough I took that a few times because I didn’t have ibuprofen and I do feel like it helped a lot with the weird long symptoms I am experiencing. I’m triple vaccinated before anyone asks. I haven’t tested positive for Covid on rapid tests but a lot of people seem to be in the boat I’m in right now.
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- 2022Hacker News 讨论帖233 分 · 219 评
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