神经科学与心理学2025science.org
在群体尺度上刺激单个光感受器以产生新颜色
Novel color via stimulation of individual photoreceptors at population scale
入门 · 约 45 分钟读完前置知识：视锥细胞与三色视觉基础、色彩感知常识
导读
这篇论文通过视网膜激光系统逐个刺激视锥细胞，在群体尺度上让受试者看到了一种自然界不存在的新颜色“olo”——即单独激活 M 视锥细胞（绿色视锥）所产生的颜色。实验招募了五名受试者，通过对照验证了这种颜色体验无法通过普通光谱刺激再现。
HN 关注点：HN 读者对“用技术让人看到从未见过的颜色”这一突破感到新奇，同时讨论其安全性、实验方法及屏幕无法显示该颜色的局限。
HN 评论精选
这几条评论里：质疑 2 补充 1 亲历 1
亲历分享亲历：单波长激光看真紫色的体验，并认为 olo 接近 #00FFEE
这让我想起一个趣闻：很多人其实从未见过真正的“紫罗兰色”（单一波长的可见光），因为现实中几乎没有物体只反射这个波长。我们看到的紫色都是红蓝混合形成的。我为此买了支 405nm 激光手电，邀请朋友在家派对上“看真正的紫罗兰色”，体验确实不同。olo 实验很有趣，说明我们如今已能逐个刺激单个视锥细胞。目前屏幕无法显示 olo，所以相关文章里都没有它的图片——我觉得它很接近 #00FFEE，并把它设为我 HN 顶栏的颜色。
tianqi查看英文原文
This story makes me remember that I had heard a fun fact a long time ago that many people have never actually seen the colour "violet" which is a single wavelength of visible light. Because there are very few things that reflect only this wavelength in reality. The purple colour we see is formed from a mixture of red and blue, whether it's something in nature, screen displaying or printing. I was so intrigued that I bought a 405nm laser torch and invited some friends to a home party to ‘See the real violet’. That single wavelength of purple really made a different experience, and with good friends, we had a great day. The olo experiment was very interesting, and it told me that today we even have the technology to stimulate a single cone cell one by one in time. I know that we can't accurately display the olo on screen right now, which also prevents any of these articles from actually containing a picture of the olo. I think it's very close to #00FFEE, and I'm making it the colour of my Hacker News's top bar.
质疑担忧：给大脑非自然刺激可能带来意外后果
他们没触发缓冲区溢出算走运了 :-) 不过认真说，大脑接收一种它从未自然接收过的刺激，可能产生某种意外的严重后果，这并非完全不可能。也许没有生物学上的对应情况，但电路和计算机里出现这种输入时显然可能出问题。
foota查看英文原文
My shitpost is that they're lucky they didn't trigger a buffer overflow :-) but really, it doesn't seem completely out of question to me that it's possible that some unintended and serious consequence could occur from your brain receiving some stimulus that it doesn't naturally receive. I guess maybe there's no biological analog, but obviously bad things can happen in circuits, computers, etc., when this happens.
质疑质疑实验伦理：受试者多为作者本人和同事
论文提到五名受试者中，三名是论文合著者，虽对测试条件不知情但了解研究目的；另外两名是华盛顿大学参与实验室的成员，对研究目的完全不知情。作者在自己和同事身上做实验，这正常吗？还是他们不想用激光刺激陌生人的感光细胞？
jonas21查看英文原文
> Five subjects were recruited for this experiment ... Subjects 10001R, 10003L, and 20205R are coauthors on the paper and were blinded to the test conditions but were aware of the purposes of the study. The other two subjects were members of the participating lab at the University of Washington but were naive to the purposes of the study. Is it normal for the authors to experiment on themselves and their colleagues like this? Or did they not like the idea of laser-stimulating the photoreceptors of random strangers?
补充补充资料：介绍“不可能颜色”，并分享激光伤眼后看到怪异颜色的经历
维基百科有“不可能颜色”的条目，有些在家就能体验：比如双眼分别看红色和绿色并交叉视线，可能看到从未见过的新颜色。我在高帧率快速切换颜色的屏幕上也会看到怪异颜色。还有一次我的眼睛被激光照射，部分视力被破坏，最初在那个位置看到了一种从未见过的虹彩银绿色——虽然挺酷，但不建议为了看这种颜色而重复这种非自愿实验。
InsideOutSanta查看英文原文
There are a bunch of "weird" colors that we don't see naturally. Wikipedia has a page on them: https://en.wikipedia.org/wiki/Impossible_color Some can be created at home without any special equipment. For example, you can't mix red and green and create a "redgreen," but if you cross your eyes and have one eye see red and the other see green, you might see a new color you haven't seen before. I also see weird colors in displays with a high frame rate that cycle between colors quickly. And at one point, I had a laser shot in my eye, which destroyed part of my vision. Initially, in that spot, I saw a weird iridescent silver-greenish color I had never seen before. Although that was pretty cool, I wouldn't recommend repeating this involuntary experiment just to see that color.
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